Abstract :

Cocrystallization Is A Useful Solid-state Approach For Modifying The Physicochemical Properties Of An Active Pharmaceutical Ingredient Without Changing Its Molecular Structure. In The Present Work, Cetirizine Dihydrochloride Was Combined Separately With Benzoic Acid And Salicylic Acid As Coformers Using 1:1 Liquid-assisted Grinding With Ethanol. The Two Solid Products Were Obtained In Masses Of 0.56 G And 0.53 G, Respectively, After 30–45 Min Of Manual Grinding. Their Observed Melting Points Were 158 °C For The Benzoic-acid System And 144 °C For The Salicylic-acid System. Mercury Software Was Used To Examine Possible Intermolecular Interactions And To Visualize Crystal-packing Features. The Dissertation Also Included A Reported Crystallographic Structure Of A Related Cetirizinium Salt, Which Showed A Monoclinic P21 Arrangement, An Extensive Hydrogen-bonding Network And Additional π–π Interactions. This Crystallographic Dataset Is Treated Here As Comparative Structural Information Rather Than As Direct Experimental Evidence For The Two Prepared Products. The Meltingpoint Changes And The Predicted Hydrogen-bonding Possibilities Support Further Investigation Of The Prepared Systems; However, Formation Of True Cocrystals Cannot Be Established From Melting-point Data And Molecular Modelling Alone. Experimental PXRD And FTIR Measurements, Together With Appropriate Thermal Analysis, Are Therefore Required For Definitive Solid-form Assignment. The Study Provides A Simple Preliminary Route For Screening Carboxylic-acid Coformers With Cetirizine Dihydrochloride.

Published:

25-12-2024

Issue:

Vol. 24 No. 12 (2024)

Page Nos:

347-353

Section:

Articles

License:

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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